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Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis

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Purine and glutamate metabolism were the top hits, suggesting perhaps ATP and glutathione biology are impacted

Koppen LM, Whitaker A, Rosene A, Beckett RD. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid Based Complementary Altern Med. 2017;22(4):956-968. doi:10.1177/2156587216687695

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